Task 6.1 aims to demonstrate the capabilities of the INDICATE platform for the aggregation of ICU datasets for secondary analysis and the development of clinically relevant AI algorithms by establishing an ’Atlas of anonymized Acute Care cases’ which we named MIMIC-EU.
The MIMIC-EU workgroup will be coordinated by the SCO with contributions from experts in WPs 2, 3, 4 and 5. The data will include multiparameter physiological signals, laboratory test results, ICU procedures, medications, imaging reports, caregiver notes and clinical outcomes such as ICU- and in-hospital mortality, organ failure, organ support, length of stay etc.
MIMIC-EU will further have the potential to be enriched with multi-modal data from several additional sources, including clinical notes from local electronic health records, clinical images adhering to EUCAIM Standards, and data from pre- ICU and post-ICU admission, as well as post-discharge information. Development will take an iterative approach, starting with the onboarding of mature and leading data providers (UDUS, CHU-Rennes) and continuously on- board more data providers thereafter. This approach will serve scientific purposes and will at the same time provide the backbone for the relevant deliverables and other use cases.
This task includes:
T6.1.1
Establishment of the formal MIMIC-EU workgroup that will collaborate with the Data Provider Support Office and the coordinators of Define minimal datasets task (WP2) to define a minimal viable dataset and associated common data model and anonymisation requirements.
T6.1.2
Drafting of template data access agreements and terms of use for data providers with the MIMIC- EU workgroup with the aid of experts from the ELSI framework task (WP3).
T6.1.3
Integrate the MIMIC-EU atlas of anonymous care cases with the centralised metadata catalogue as a predefined selection across the federated infrastructure for ICU data.
T6.1.4
Create a synthetic, fully anonymous dataset based on the full federated MIMIC-EU data to allow data users to test and validate data access requests and jobs prior to distribution and execution across the infrastructure.
T6.1.5
Implement a secure workspace based on the templates developed in the Minimal Viable Product (MVP) versions of Core services and data federation network – task (WP4), where data users may bring their own tools or can utilise predefined tools.
T6.1.6
Implement the security and quality policies and gates developed in WP4 to mitigate data protection risks and promote cyber security.
T6.1.7
Create a set of straightforward analyses to showcase MIMIC-EU for promotion purposes.
This will include analyses of important clinical scenarios and questions. Examples include a deeper analysis of hemodynamic monitoring in cardiogenic shock and sepsis, glucose metabolism in ICU patients, and regional differences in treatment strategies also in relation to resource allocation strategies. Furthermore, rare diseases will be analyses as well as treatment trajectories of old and very old patients and cancer patients. In these projects all partners of the academic hospitals in the consortium will be involved.
Use case leader
